The eNOTICE-2 project aims to enhance preparedness for Chemical, Biological, Radiological, and Nuclear (CBRN) events, whether they arise from deliberate, accidental, or natural causes. Building on the insights, gaps, and needs identified by the eNOTICE Network of Practitioners, the project focuses on improving overall readiness and response capabilities for major cross-border crises involving CBRN agents or their combinations. A wide range of stakeholders are engaged in this effort, including CBRN practitioners, technology developers, policymakers, and civilian volunteers.